PFO closure using resorbable occluders

Resorbable occluders are a catheter-based treatment option designed to close a patent foramen ovale without leaving a permanent implant inside the heart. The device provides temporary mechanical support and gradually dissolves over time.

This concept is particularly attractive for patients who wish to avoid a permanent metal implant.

What does resorbable PFO closure mean?

In resorbable PFO closure, a temporary occluder is placed across the interatrial septum to seal the PFO. Over time, the material is resorbed, while functional closure of the PFO is maintained.

With current techniques, most patients are anatomically suitable, although individual evaluation remains essential.

Which resorbable device is used today?

At present, we use the Memosorb occluder.

Based on our clinical experience, this technique is very safe. A recent randomized study has demonstrated non-inferiority compared with established device-based closure, meaning the study met its primary endpoint.

The Memosorb occluder is currently approved in China, where more than 3,000 devices have been implanted. Outside China, the device can be used under compassionate-use criteria.

Who may benefit from resorbable occluders?

Resorbable PFO closure may be considered in patients who prefer a metal-free closure strategy.

Indications are similar to those for suture-based closure. In addition, resorbable occluders can be an option in patients who are not suitable for suture-based techniques due to anatomical reasons.

Final suitability depends on individual anatomy and clinical context and must be evaluated on a case-by-case basis.

Evidence and clinical experience

Clinical experience with resorbable occluders is growing. While long-term data are more limited than for conventional metal devices, available evidence and real-world experience support the safety and effectiveness of this approach in selected patients.

As with all PFO closure techniques, careful patient selection and experienced procedural performance are essential.

Benefits and limitations

The main advantage of resorbable occluders is avoidance of a permanent metal implant.

Limitations include regulatory availability and currently more limited long-term follow-up compared with established occluder devices. Potential benefits and risks must therefore be discussed individually.

Recovery

Resorbable PFO closure is performed as a minimally invasive catheter procedure. In most cases, patients are treated on an outpatient basis and discharged on the same day. Normal daily activities can usually be resumed shortly thereafter.

Individual decision making

We consider resorbable occluders as one of several valid metal-free treatment options for PFO closure. The final decision is based on anatomy, clinical context, patient preferences, and alternative strategies.

For patients interested in other metal-free approaches, information on suture-based PFO closure is available on a separate page.